Animálculos

#04 | DNA – História da descoberta

Na semana de aniversário do artigo na Nature do Watson e Crick que mudou o mundo, vamos conversar sobre os principais pesquisadores e eventos que levaram a descrição da molécula de DNA. Vamos falar de Mendel e os experimentos com as ervilhas, e de Rosalind Franklin que teve a famosa foto 51 mostrada sem autorização para o Watson e logo publicou a estrutura do DNA. E o modelo proposto por Linus Pauling, qual foi o principal erro? O Convidado desse quorum sensing é o Dr. Daniel Kumazawa do Instituto de Microbiologia da Academia de Ciência da República Tcheca. Se você ainda não segue o Podcast no instagram, procura lá por @animalculo.podcast - Sempre tem material extra. Lista Cronológica da história de descrição do DNA e artigos citados nesse episódio. •March 30, 1933: Note: "The Structure of Thymus Nucleic Acid." March 30, 1933. •Paper: Title page for "The Nature of the Chemical Bond," second edition. 1940. •Note: "The Nature of the Intermolecular Forces Operative in Biological Processes." 1940. •January 1944: Paper: "Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III." January 1944. •Paper: "X-Ray Studies of Nucleic Acids." 1947. •Paper: "Molecular Architecture and the Processes of Life." May 28, 1948. •Picture: Oil portrait of Linus Pauling, featuring a model of the alpha-helix in the foreground. 1951. •Paper: "Atomic coordinates and structure factors for two helical configurations of polypeptide chains." April - May 1951. •Paper: "The structure of synthetic polypeptides." April - May 1951. •Paper: "The pleated sheet, a new layer configuration of polypeptide chains." April - May 1951. •Paper: "The polypeptide-chain configuration in hemoglobin and other globular proteins." April - May 1951. •August 28, 1951 •Correspondence: Letter from J. T. Randall (FISICO QUE AJUDOU NAESTRUTURA DO DNA) to Linus Pauling. August 28, 1951. •Correspondence: Letter from Linus Pauling to J. T. Randall. September 25, 1951. •Picture: Diagram of the Ronwin structure for the nucleic acids. November 1951. •Picture: George Beadle and Linus Pauling examining a skeletal model of a polypeptide chain, California Institute of Technology. 1952. •Picture: Crystallographic photo of Sodium Thymonucleate, Type B. "Photo 51." May 1952. •Correspondence: Letter from Alexander Todd (SENTIDO 3’ -> 5’) to Linus Pauling. May 6, 1952. •Paper: "Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage." September 20, 1952. •Note: "The π Helix - A Hydrogen Bonded Configuration of the Polypeptide Chain." October 30, 1952. •November - December 1952 •Note: "A Proposed Structure for the Nucleic Acids." November - December 1952. •Note: "Atomic Coordinates for Nucleic Acid." December 20, 1952. •Picture: Segment of the original Watson and Crick DNA model. 1953. •Picture: The original DNA demonstration model, designed by James Watson and Francis Crick. approx. 1953. •Note: "A Note on Molecular Configuration in Sodium Thymonucleate." approx. 1953. •TROCA de mensagens entre Linus Pauling e Nature •Paper: "Structure of the nucleic acids." February 1953. •Paper: "A proposed structure for the nucleic acids." February 1953. •Note: "The Structure of Deoxyribose Nucleic Acid." March 17, 1953. •April 25, 1953 Artigo de descrição da molécula de DNA •Paper: "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid." April 25, 1953.