#2 Junho 2023 - Oseltamivir, mais insulina, mais ervas chinesas, chat GPT4, HIPÓTESE NULA & outros

Notas do episódio

2º episódio, aqui vai ele. Ficou um pouco maior do que queria, sobretudo porque estava sem o travão dos meus amigos Pedro e Mariana. Espero que 40 minutos não seja demasiado. Caso seja, acho que o principal é dito nos 1os 20-30minutos. Até amanhã. Blogue esFOAMeados --- GLOSSÁRIO RS de ECAs Doente crítico/urgente · Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock | NEJM Evidence Infecciologia, Microbiologia & Antimicrobianos · Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza | JAMA Internal Medicine ECAs Cardiovascular · Angiotensin-Neprilysin Inhibition in Mildly Reduced or Preserved EF and Worsening Heart Failure | JACC · Self-administered IN etripamil w/ symptom-prompted, repeat-dose regimen for AVN-dependent SVT - RAPID | Lancet Doente crítico/urgente · Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults - DEVICE | NEJM Endocrinologia · Insulina icodec o Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Insulin-Naive T2D - ONWARDS 2 | JAMA o Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin - ONWARDS 1 | NEJM · Incretinas o Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity | JAMA Network Open o Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial | NEJM Gastroenterologia & Hepatologia · Randomized placebo-controlled phase 3 trial of vibrating capsule for chronic constipation | Gastroenterology Geral, Geriatria & Paliativos · Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness | JAMA Hematologia · Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia - PACER | NEJM Infecciologia, Microbiologia & Antimicrobianos · Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis - MERCY | JAMA Nefrologia · Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure - CONVINCE | NEJM · Balanced crystalloid solution versus saline in deceased donor kidney transplantation - BEST-Fluids | Lancet Neurologia · Early versus Later Anticoagulation for Stroke with Atrial Fibrillation - ELAN | NEJM · Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China | JAMA Network Open · Butylphthalide in Patients With Acute Ischemic Stroke - BAST | JAMA Neurology Neurologia/ORL/Doente urgente · Semont-Plus or Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo | JAMA Neurology --- Normas de Orientação --- Diagnóstico / Raciocínio Clínico e MCDs · Joint Advisory Statement: Emergency CT scans and IV Iodinated Contrast | RCEM-RCR --- Observacionais --- Revisões Sistemáticas Doente crítico/urgente · Observation, aspiration, or tube-thoracostomy for primary spontaneous pneumothorax | Chest Primários - Sub-análise / Coorte / Caso-controlo / Inquéritos / Análises económicas Cardiovascular · P2Y12 Inhibitor Monotherapy / Dual Antiplatelet Therapy After Complex PCI | JACC · Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults | JAMA IM · Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients w/ AF | AIM Diagnóstico & Raciocínio Clínico · Accuracy of a Generative Artificial Intelligence Model in a Complex Diagnostic Challenge | JAMA Network Open · Clinically significant contrast-associated AKI after emergent CT angiography of the cerebral arteries | EJIM Meta-investigação & MBE · Lack of Treatment Efficacy Derived From Statistically Nonsignificant Results of Randomized Clinical Trials | JAMA · Prolific non-research authors in high impact scientific journals: meta-research study | Scientometrics Perspectiva Geral · Update in Outpatient General Internal Medicine: Practice-Changing Evidence Published in 2022 | AJM Meta-investigação & MBE · Detecting Selection Bias in Observational Studies—When Interventions Work Too Fast | JAMA Internal Medicine · Promoting Ethical Integrity in Authorship Attribution: Who Can Help More? | Acta Médica Portuguesa · Catalogue of bias: novelty bias | BMJ-EBM