#017.1 | Fasting, Keto and Longevity, with gerontologist James Clement (part 2 – English).

Notas do episódio

Welcome to part 2 of our masterclass about fasting, keto and longevity with American biogerontologist James Clement. Please listen to part 1 on our channel as well. ***** Disclaimer in Portuguese: Este programa foi gravado totalmente em inglês. A versão do Youtube conta com legendas em inglês e em português, e em breve disponibilizaremos também uma edição dublada em áudio. ***** On this episode: (4:46) Real-life examples of the association of fasting/CR and longevity: the Okinawans, the Loma Linda adventists and the Mount Athos Monks. Dog breeds and longevity: why miniature dogs live longer, and what it has to do with fasting. (7:52) IGF–1 hormone activity and mTOR through evolution: a mechanism of survival during starvation. The switch from eating organs to muscles and its impact on our health. Centenarians' short stature and IGF–1 mutation. (13:07) Excessive growth and its association with the "diseases of civilization": how colonization impacted negatively the health of several communities. (15:35) Who should reap the most benefits from fasting? Should lean people fast? Fasting, eating disorders, pregnancy and the heterogeneity of humankind. (18:48) Transitioning to keto: overcoming "keto flu", cravings and other challenges. The role of bacteria on the adaptation. The importance of water and electrolyte balance. (22:47) Prolonged fasting: benefits and challenges of going without food for over 48 hours. Is it necessary for optimizing mTOR and autophagy, or could you get by with daily intermittent fasting? (29:47) Excessive protein intake and lifespan: why eating too much meat will probably make you live less. (31:31) The era of epigenetic clocks: determining your true biological age by DNA Methylation patterns. Breaking down the pioneer work of Steve Horvath and Morgan Levine. The different golden-standard methods: DNAm, PhenoAge and GrimAge. (43:53) The importance of taking blood tests periodically and which ones to take. (48:47) Why we age: David Sinclair's theory of loss of information. The research on NAD as a longevity-promoting substance. (52:19) James' optimistic vision about the future: how the research and investment boom on the longevity field, access to information and low-cost treatments should impact positively our future as a species.