#20 - O metabolismo mede tempo ou mede energia?

Notas do episódio

Neste episódio vimos como o metabolismo é muito mais sofisticado do que o senso comum, que tenta simplificá-lo em "transformar comida em energia", entre outras reduções que não fazem jus! Refs.: ALON, Uri. An Introduction to Systems Biology: Design Principles of Biological Circuits. 2. ed. Boca Raton: Chapman & Hall/CRC, 2019. BALCH, William E.; MORIMOTO, Richard I.; DILLIN, Andrew; KELLY, Jeffery W. Adapting proteostasis for disease intervention. Science, Washington, v. 319, n. 5865, p. 916–919, 2008. DOI: https://doi.org/10.1126/science.1141448 BASS, Joseph; TAKAHASHI, Joseph S. Circadian integration of metabolism and energetics. Science, Washington, v. 330, n. 6009, p. 1349–1354, 2010. DOI: https://doi.org/10.1126/science.1195027 BECHTEL, William. Discovering Cell Mechanisms: The Creation of Modern Cell Biology. Cambridge: Cambridge University Press, 2006. GUYTON, Arthur C.; HALL, John E. Tratado de Fisiologia Médica. 14. ed. Rio de Janeiro: Elsevier, 2021. HARDIE, D. Grahame. AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels. Annual Review of Nutrition, Palo Alto, v. 34, p. 31–55, 2014. DOI: https://doi.org/10.1146/annurev-nutr-071812-161148 HARDIE, D. Grahame. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nature Reviews Molecular Cell Biology, London, v. 8, n. 10, p. 774–785, 2007. DOI: https://doi.org/10.1038/nrm2249 INGBER, Donald E. Mechanobiology and diseases of mechanotransduction. Annals of Medicine, London, v. 35, n. 8, p. 564–577, 2003. DOI: https://doi.org/10.1080/07853890310016333 KITANO, Hiroaki. Systems biology: a brief overview. Science, Washington, v. 295, n. 5560, p. 1662–1664, 2002. DOI: https://doi.org/10.1126/science.1069492 KIRKWOOD, Thomas B. L. Evolution of ageing. Nature, London, v. 270, p. 301–304, 1977. DOI: https://doi.org/10.1038/270301a0 LÓPEZ-OTÍN, Carlos et al. Hallmarks of aging: an expanding universe. Cell, Cambridge, v. 186, n. 2, p. 243–278, 2023. DOI: https://doi.org/10.1016/j.cell.2022.11.001 NICHOLLS, David G.; FERGUSON, Stuart J. Bioenergetics. 4. ed. London: Academic Press, 2013. NOBLE, Denis. The Music of Life: Biology Beyond Genes. Oxford: Oxford University Press, 2006. OHSUMI, Yoshinori. Historical landmarks of autophagy research. Cell Research, Shanghai, v. 24, n. 1, p. 9–23, 2014. DOI: https://doi.org/10.1038/cr.2013.169 PRIGOGINE, Ilya; STENGERS, Isabelle. Order Out of Chaos: Man's New Dialogue with Nature. New York: Bantam Books, 1984. SAXTON, Robert A.; SABATINI, David M. mTOR signaling in growth, metabolism, and disease. Cell, Cambridge, v. 168, n. 6, p. 960–976, 2017. DOI: https://doi.org/10.1016/j.cell.2017.02.004 SCHRÖDINGER, Erwin. What is Life? The Physical Aspect of the Living Cell. Cambridge: Cambridge University Press, 1944. SHANNON, Claude E. A mathematical theory of communication. Bell System Technical Journal, New York, v. 27, n. 3, p. 379–423, 1948. DOI: https://doi.org/10.1002/j.1538-7305.1948.tb01338.x SIMON, Herbert A. The Sciences of the Artificial. 3. ed. Cambridge: MIT Press, 1996. SINCLAIR, David A.; GUARENTE, Leonard. Small-molecule allosteric activators of sirtuins. Annual Review of Pharmacology and Toxicology, Palo Alto, v. 54, p. 363–380, 2014. DOI: https://doi.org/10.1146/annurev-pharmtox-010611-134657 STERLING, Peter. What Is Health? Allostasis and the Evolution of Human Design. Cambridge: MIT Press, 2020. VON NEUMANN, John. Theory of Self-Reproducing Automata. Urbana: University of Illinois Press, 1966. WEST, Geoffrey. Scale: The Universal Laws of Life, Growth, and Death in Organisms, Cities, and Companies. New York: Penguin Press, 2017. Se deseja marcar uma consulta, mande mensagem no email profbaeta@gmail.com ou entre no site www.lucabaeta.com.br ou ainda, se preferir, mande mensagem no instagram @profbaeta